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Anti-ATP5A1 Antibody

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产品名称: Anti-ATP5A1 Antibody
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Anti-ATP5A1 Antibody


Anti-ATP5A1 Antibody  的详细介绍
Name: Anti-ATP5A1 Antibody
See all ATP5A1 primary antibodies
Description: Rabbit polyclonal antibody to ATP5A1
Specificity: The antibody detects endogenous level of total ATP5A1 antibody.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATP5A1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-s (By similarity).
Tissue Specificity: Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.
Involvement in Disease: Combined oxidative phosphorylation deficiency 22: A mitochondrial disorder characterized by intrauterine growth retardation, microcephaly, hypotonia, pulmonary hypertension, failure to thrive, encephalopathy, and heart failure.

Mitochondrial complex V deficiency, nuclear 4: A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
Sequence Similarities: Belongs to the ATPase alpha/beta chains family.
Post-Translational Modification: The N-terminus is blocked.
Cellular Location: Mitochondrion inner membrane. Cell membrane.

Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951).
Database Links:
  • Entrez Gene: 498 Human
  • Entrez Gene: 11946 Mouse
  • Entrez Gene: 65262 Rat
  • Omim: 164360 Human
  • SwissProt: P25705 Human
  • SwissProt: Q03265 Mouse
  • SwissProt: P15999 Rat
  • Unigene: 298280 Human
  • Unigene: 276137 Mouse
  • Unigene: 474505 Mouse
  • Unigene: 40255 Rat
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    Synonyms:
  • ATP synthase alpha chain, mitochondrial Antibody
  • ATP synthase subunit alpha Antibody
  • ATP synthase subunit alpha mitochondrial Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, 1 Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2 Antibody
  • ATP sythase (F1 ATPase) alpha subunit Antibody
  • ATP5A Antibody
  • Atp5a1 Antibody
  • ATP5AL2 Antibody
  • ATPA_HUMAN Antibody
  • ATPM Antibody
  • Epididymis secretory sperm binding protein Li 123m Antibody
  • hATP1 Antibody
  • HEL-S-123m Antibody
  • MC5DN4 Antibody
  • mitochondrial Antibody
  • Mitochondrial ATP synthetase Antibody
  • Mitochondrial ATP synthetase oligomycin resistant Antibody
  • Modifier of Min 2 mouse homolog Antibody
  • Modifier of Min 2, mouse, homolog of Antibody
  • MOM2 Antibody
  • OMR Antibody
  • ORM Antibody
  • OTTHUMP00000163475 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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