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Anti-ATP5A (K239) Antibody

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产品名称: Anti-ATP5A (K239) Antibody
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Anti-ATP5A (K239) Antibody


Anti-ATP5A (K239) Antibody  的详细介绍
Name: Anti-ATP5A (K239) Antibody
See all ATP5A primary antibodies
Description: Rabbit polyclonal antibody to ATP5A (K239)
Specificity: ATP5A (K239) pAb detects endogenous levels of ATP5A protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 210-260 of Human ATP5A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-s (By similarity).
Tissue Specificity: Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.
Involvement in Disease: Combined oxidative phosphorylation deficiency 22: A mitochondrial disorder characterized by intrauterine growth retardation, microcephaly, hypotonia, pulmonary hypertension, failure to thrive, encephalopathy, and heart failure.

Mitochondrial complex V deficiency, nuclear 4: A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid.
Sequence Similarities: Belongs to the ATPase alpha/beta chains family.
Post-Translational Modification: The N-terminus is blocked.
Cellular Location: Mitochondrion inner membrane. Cell membrane.

Colocalizes with HRG on the cell surface of T-cells (PubMed:19285951).
Database Links:
  • Entrez Gene: 498?Human
  • Entrez Gene: 11946?Mouse
  • Entrez Gene: 65262?Rat
  • Omim: 164360?Human
  • SwissProt: P25705?Human
  • SwissProt: Q03265?Mouse
  • SwissProt: P15999?Rat
  • Unigene: 298280?Human
  • Unigene: 276137?Mouse
  • Unigene: 474505?Mouse
  • Unigene: 40255?Rat
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    Synonyms:
  • ATP synthase alpha chain, mitochondrial Antibody
  • ATP synthase subunit alpha Antibody
  • ATP synthase subunit alpha mitochondrial Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, 1 Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle Antibody
  • ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2 Antibody
  • ATP sythase (F1 ATPase) alpha subunit Antibody
  • ATP5A Antibody
  • Atp5a1 Antibody
  • ATP5AL2 Antibody
  • ATPA_HUMAN Antibody
  • ATPM Antibody
  • Epididymis secretory sperm binding protein Li 123m Antibody
  • hATP1 Antibody
  • HEL-S-123m Antibody
  • MC5DN4 Antibody
  • mitochondrial Antibody
  • Mitochondrial ATP synthetase Antibody
  • Mitochondrial ATP synthetase oligomycin resistant Antibody
  • Modifier of Min 2 mouse homolog Antibody
  • Modifier of Min 2, mouse, homolog of Antibody
  • MOM2 Antibody
  • OMR Antibody
  • ORM Antibody
  • OTTHUMP00000163475 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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