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Anti-ATOH8 Antibody

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产品名称: Anti-ATOH8 Antibody
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Anti-ATOH8 Antibody


Anti-ATOH8 Antibody  的详细介绍
Name: Anti-ATOH8 Antibody
See all ATOH8 primary antibodies
Description: Rabbit polyclonal antibody to ATOH8
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 15 amino acid peptide near the carboxy terminus of human ATOH8.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248).
Tissue Specificity: Expressed by subsets of mature neurons (PubMed:11733035). Expressed in kidney (podocytes) (PubMed:16937370). Expression is restricted to the atria, lung mesenchyme, and vascular smooth muscle (PubMed:23836893).
Cellular Location: Nucleus. Nucleus speckle. Cytoplasm.
Database Links:
  • Entrez Gene: 84913?Human
  • Entrez Gene: 71093?Mouse
  • Entrez Gene: 500200?Rat
  • SwissProt: Q96SQ7?Human
  • SwissProt: Q99NA2?Mouse
  • Unigene: 135569?Human
  • Unigene: 87449?Mouse
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    Synonyms:
  • 4933425C05Rik Antibody
  • ATOH8 Antibody
  • ATOH8_HUMAN Antibody
  • Atonal homolog 6 Antibody
  • Atonal homolog 8 Antibody
  • atonal homolog 8 (Drosophila) Antibody
  • Basic helix loop helix transcription factor 6 Antibody
  • bHLHa21 Antibody
  • Class A basic helix-loop-helix protein 21 Antibody
  • FLJ14708 Antibody
  • FLJ38730 Antibody
  • hATH6 Antibody
  • Helix loop helix protein mATH-6 Antibody
  • Helix-loop-helix protein hATH-6 Antibody
  • Math6 Antibody
  • Okadin Antibody
  • Protein atonal homolog 8 Antibody
  • RGD1561512 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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