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Anti-ATG7 Antibody

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产品名称: Anti-ATG7 Antibody
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简单介绍

Anti-ATG7 Antibody


Anti-ATG7 Antibody  的详细介绍
Name: Anti-ATG7 Antibody
See all ATG7 primary antibodies
Description: Rabbit polyclonal antibody to ATG7
Specificity: ATG7 pAb detects endogenous levels of ATG7 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human ATG7.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 78 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
Tissue Specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
Sequence Similarities: Belongs to the ATG7 family.
Post-Translational Modification: Acetylated by EP300.
Cellular Location: Cytoplasm. Preautophagosomal structure.

Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Database Links:
  • Entrez Gene: 10533?Human
  • Entrez Gene: 74244?Mouse
  • Entrez Gene: 312647?Rat
  • Omim: 608760?Human
  • SwissProt: O95352?Human
  • SwissProt: Q9D906?Mouse
  • SwissProt: Q641Y5?Rat
  • Unigene: 38032?Human
  • Unigene: 275332?Mouse
  • Unigene: 162765?Rat
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    Synonyms:
  • 1810013K23Rik Antibody
  • Apg 7 Antibody
  • Apg7 Antibody
  • APG7 autophagy 7 like Antibody
  • APG7 autophagy 7-like (S. cerevisiae) Antibody
  • APG7 like Antibody
  • APG7, S. cerevisiae, homolog of Antibody
  • APG7-like Antibody
  • APG7L Antibody
  • ATG 7 Antibody
  • ATG12-activating enzyme E1 ATG7 Antibody
  • ATG7 Antibody
  • ATG7 autophagy related 7 homolog Antibody
  • ATG7 autophagy related 7 homolog (S. cerevisiae) Antibody
  • Atg7l Antibody
  • ATG7_HUMAN Antibody
  • Autophagy 7, S. cerevisiae, homolog of Antibody
  • Autophagy related protein 7 Antibody
  • Autophagy-related 7 (yeast) Antibody
  • Autophagy-related protein 7 Antibody
  • DKFZp434N0735 Antibody
  • GSA 7 Antibody
  • GSA7 Antibody
  • hAGP7 Antibody
  • Ubiquitin activating enzyme E1 like protein Antibody
  • Ubiquitin-activating enzyme E1-like protein Antibody
  • Ubiquitin-like modifier-activating enzyme ATG7 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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