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Anti-ATG4D Antibody

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产品名称: Anti-ATG4D Antibody
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Anti-ATG4D Antibody


Anti-ATG4D Antibody  的详细介绍
Name: Anti-ATG4D Antibody
See all ATG4D primary antibodies
Description: Rabbit polyclonal antibody to ATG4D
Specificity: The antibody detects endogenous levels of total ATG4D protein.
Applications: IHC
Reactivity: Human
Immunogen: Full length fusion protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.7mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Tissue Specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis.
Sequence Similarities: Belongs to the peptidase C54 family.
Post-Translational Modification: Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondroal import of the protein.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 84971?Human
  • Omim: 611340?Human
  • SwissProt: Q86TL0?Human
  • Unigene: 512799?Human
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    Synonyms:
  • 9830134P12Rik Antibody
  • APG4 autophagy 4 homolog D Antibody
  • APG4 D Antibody
  • APG4, S. cerevisiae, homolog of, D Antibody
  • APG4D Antibody
  • ATG4 autophagy related 4 homolog D (S. cerevisiae) Antibody
  • ATG4D Antibody
  • Atg4dl Antibody
  • ATG4D_HUMAN Antibody
  • AUT like 4 cysteine endopeptidase Antibody
  • AUT-like 4 cysteine endopeptidase Antibody
  • AUTL4 Antibody
  • Autophagin 4 Antibody
  • Autophagin-4 Antibody
  • autophagy 4, S. cerevisiae, homolog of, D Antibody
  • autophagy related 4D, cysteine peptidase Antibody
  • Autophagy related cysteine endopeptidase 4 Antibody
  • Autophagy related protein 4 homolog D Antibody
  • Autophagy-related cysteine endopeptidase 4 Antibody
  • Autophagy-related protein 4 homolog D Antibody
  • Cysteine protease ATG4D Antibody
  • Cysteine protease involved in autophagy Antibody
  • MGC31226 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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