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Anti-ATG12 (S129) Antibody

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产品名称: Anti-ATG12 (S129) Antibody
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Anti-ATG12 (S129) Antibody


Anti-ATG12 (S129) Antibody  的详细介绍
Name: Anti-ATG12 (S129) Antibody
See all ATG12 primary antibodies
Description: Rabbit polyclonal antibody to ATG12 (S129)
Specificity: ATG12 (S129) pAb detects endogenous levels of ATG12 protein.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: A synthetic peptide corresponding to residues in Human ATG12.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 15, 50 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Function: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Tissue Specificity: Ubiquitous.
Sequence Similarities: Belongs to the ATG12 family.
Post-Translational Modification: Acetylated by EP300.
Cellular Location: Cytoplasm. Preautophagosomal structure membrane.

TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Database Links:
  • Entrez Gene: 9140 Human
  • Entrez Gene: 67526 Mouse
  • Entrez Gene: 361321 Rat
  • Omim: 609608 Human
  • SwissProt: O94817 Human
  • SwissProt: Q9CQY1 Mouse
  • SwissProt: Q2TBJ5 Rat
  • Unigene: 264482 Human
  • Unigene: 9852 Mouse
  • Unigene: 6224 Rat
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    Synonyms:
  • Apg12 Antibody
  • APG12-like Antibody
  • APG12L Antibody
  • ATG12 Antibody
  • ATG12 autophagy related 12 homolog Antibody
  • ATG12 autophagy related 12 homolog (S. cerevisiae) Antibody
  • ATG12_HUMAN Antibody
  • Autophagy 12 Antibody
  • Autophagy-related protein 12 Antibody
  • FBR93 Antibody
  • HAPG12 Antibody
  • Ubiquitin-like protein ATG12 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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