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Anti-ATF7 Antibody

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产品名称: Anti-ATF7 Antibody
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简单介绍

Anti-ATF7 Antibody


Anti-ATF7 Antibody  的详细介绍
Name: Anti-ATF7 Antibody
See all ATF7 primary antibodies
Description: Rabbit polyclonal antibody to ATF7.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse
Immunogen: Recombinant protein of human ATF7.
Protein Length: 494 (117)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
Tissue Specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Sequence Similarities: Belongs to the bZIP family.
Post-Translational Modification: On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
Cellular Location: Nucleus. Nucleus > Nucleoplasm.

Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
Database Links:
  • Entrez Gene: 11016?Human
  • Entrez Gene: 223922?Mouse
  • Omim: 606371?Human
  • SwissProt: P17544?Human
  • SwissProt: Q8R0S1?Mouse
  • Unigene: 12286?Human
  • Unigene: 208714?Mouse
  • Unigene: 475149?Mouse
    		•
    Synonyms:
  • 1110012F10Rik Antibody
  • 9430065F09Rik Antibody
  • Activating transcription factor 7 Antibody
  • AI549878 Antibody
  • ATF7 Antibody
  • Atf7 protein Antibody
  • ATF7_HUMAN Antibody
  • ATFA Antibody
  • C130020M04Rik Antibody
  • cAMP-dependent transcription factor ATF-7 Antibody
  • Cyclic AMP-dependent transcription factor ATF 7 Antibody
  • Cyclic AMP-dependent transcription factor ATF-7 Antibody
  • MGC31554 Antibody
  • MGC57182 Antibody
  • Transcription factor ATF A Antibody
  • Transcription factor ATF-A Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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