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Anti-ATF1 Antibody

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产品名称: Anti-ATF1 Antibody
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简单介绍

Anti-ATF1 Antibody


Anti-ATF1 Antibody  的详细介绍
Name: Anti-ATF1 Antibody
See all ATF1 primary antibodies
Description: Rabbit polyclonal antibody to ATF1
Specificity: The antibody detects endogenous levels of total ATF1 protein.
Applications: WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human ATF1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Involvement in Disease: Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities: Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification: Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 466 Human
  • Entrez Gene: 11908 Mouse
  • Entrez Gene: 315305 Rat
  • Omim: 123803 Human
  • SwissProt: P18846 Human
  • SwissProt: P81269 Mouse
  • Unigene: 648565 Human
  • Unigene: 473546 Mouse
  • Unigene: 676 Mouse
  • Unigene: 105304 Rat
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    Synonyms:
  • Activating transcription factor 1 Antibody
  • ATF 1 Antibody
  • ATF1 Antibody
  • ATF1 EWS fusion gene Antibody
  • ATF1 FUS fusion gene Antibody
  • ATF1_HUMAN Antibody
  • cAMP dependent transcription factor 1 Antibody
  • cAMP-dependent transcription factor ATF-1 Antibody
  • Cyclic AMP dependent transcription factor ATF 1 Antibody
  • Cyclic AMP dependent transcription factor ATF1 Antibody
  • Cyclic AMP-dependent transcription factor ATF-1 Antibody
  • EWS AFT1 Antibody
  • FUS ATF 1 Antibody
  • FUS/ATF 1 Antibody
  • Protein TREB36 Antibody
  • RNA binding protein activating transcription factor 1 fusion protein Antibody
  • TREB 36 Antibody
  • TREB36 Antibody
  • TREB36 protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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