产品资料

Anti-ATF1 (T209) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ATF1 (T209) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ATF1 (T209) Antibody


Anti-ATF1 (T209) Antibody  的详细介绍
Name: Anti-ATF1 (T209) Antibody
See all ATF1 primary antibodies
Description: Rabbit polyclonal antibody to ATF1 (T209)
Specificity: ATF1 (T209) pAb detects endogenous levels of ATF1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 170-220 of Human ATF1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 29, 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Involvement in Disease: Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities: Belongs to the bZIP family. ATF subfamily.
Post-Translational Modification: Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 466?Human
  • Entrez Gene: 11908?Mouse
  • Entrez Gene: 315305?Rat
  • Omim: 123803?Human
  • SwissProt: P18846?Human
  • SwissProt: P81269?Mouse
  • Unigene: 648565?Human
  • Unigene: 473546?Mouse
  • Unigene: 676?Mouse
  • Unigene: 105304?Rat
    		•
    Synonyms:
  • Activating transcription factor 1 Antibody
  • ATF 1 Antibody
  • ATF1 Antibody
  • ATF1 EWS fusion gene Antibody
  • ATF1 FUS fusion gene Antibody
  • ATF1_HUMAN Antibody
  • cAMP dependent transcription factor 1 Antibody
  • cAMP-dependent transcription factor ATF-1 Antibody
  • Cyclic AMP dependent transcription factor ATF 1 Antibody
  • Cyclic AMP dependent transcription factor ATF1 Antibody
  • Cyclic AMP-dependent transcription factor ATF-1 Antibody
  • EWS AFT1 Antibody
  • FUS ATF 1 Antibody
  • FUS/ATF 1 Antibody
  • Protein TREB36 Antibody
  • RNA binding protein activating transcription factor 1 fusion protein Antibody
  • TREB 36 Antibody
  • TREB36 Antibody
  • TREB36 protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号