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Anti-PODXL Antibody

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产品名称: Anti-PODXL Antibody
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Anti-PODXL Antibody


Anti-PODXL Antibody  的详细介绍
Name: Anti-PODXL Antibody
See all PODXL primary antibodies
Description: Mouse monoclonal antibody to PODXL.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: Recombinant protein of human PODXL.
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Tissue Specificity: Glomerular epithelium cell (podocyte).
Sequence Similarities: Belongs to the podocalyxin family.
Post-Translational Modification: N- and O-linked glycosylated. Sialoglycoprotein (By similarity).
Cellular Location: Apical cell membrane. Cell projection > Lamellipodium. Cell projection > Filopodium. Cell projection > Ruffle. Cell projection > Microvillus. Membrane raft. Membrane.

In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells (By similarity). Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial cells. Colocalizes with the submembrane actin of lamellipodia, particularly associated with ruffles. Colocalizes with vinculin at protrusions of cells. Colocalizes with ITGB1. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, RAB11A and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis (By similarity).
Database Links:
  • Entrez Gene: 5420?Human
  • Omim: 602632?Human
  • SwissProt: O00592?Human
  • Unigene: 744213?Human
    		•
    Synonyms:
  • GCTM-2 antigen Antibody
  • Gp2 Antibody
  • Gp200 Antibody
  • MGC138240 Antibody
  • PC Antibody
  • PCLP Antibody
  • PCLP-1 Antibody
  • PCLP1 Antibody
  • Pcx Antibody
  • Podocalyxin Antibody
  • Podocalyxin like Antibody
  • Podocalyxin like protein Antibody
  • Podocalyxin-like protein 1 Antibody
  • PODXL Antibody
  • PODXL_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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