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Anti-Podoplanin Antibody

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产品名称: Anti-Podoplanin Antibody
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简单介绍

Anti-Podoplanin Antibody


Anti-Podoplanin Antibody  的详细介绍
Name: Anti-Podoplanin Antibody
See all Podoplanin primary antibodies
Description: Rabbit polyclonal antibody to Podoplanin
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Monkey, Mouse
Immunogen: Synthetic peptide taken within amino acid region 80-130 on human Podoplanin protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Concentration: 0.55-0.75 μg/μl in antibody stabilization buffer
Storage: -20?C for long term storage
Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
Tissue Specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
Sequence Similarities: Belongs to the podoplanin family.
Post-Translational Modification: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
Cellular Location: Membrane. Cell projection > Filopodium membrane. Cell projection > Lamellipodium membrane. Cell projection > Microvillus membrane. Cell projection > Ruffle membrane.

Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
Database Links:
  • Entrez Gene: 10630?Human
  • Entrez Gene: 14726?Mouse
  • Omim: 608863?Human
  • SwissProt: Q86YL7?Human
  • SwissProt: Q62011?Mouse
  • Unigene: 468675?Human
  • Unigene: 2976?Mouse
    		•
    Synonyms:
  • Aggrus Antibody
  • Glycoprotein 36 Antibody
  • Glycoprotein 36 KD Antibody
  • gp 36 Antibody
  • GP 38 Antibody
  • GP 40 Antibody
  • gp36 Antibody
  • GP38 Antibody
  • GP40 Antibody
  • HT1A 1 Antibody
  • HT1A1 Antibody
  • hT1alpha 1 Antibody
  • hT1alpha 2 Antibody
  • hT1alpha1 Antibody
  • hT1alpha2 Antibody
  • Lung type I cell membrane associated glycoprotein Antibody
  • Lung type I cell membrane associated glycoprotein isoform a Antibody
  • Lung type I cell membrane associated glycoprotein T1A 2 Antibody
  • OTS 8 Antibody
  • OTS8 Antibody
  • OTTHUMP00000009640 Antibody
  • OTTHUMP00000044504 Antibody
  • PA2.26 Antibody
  • PA2.26 antigen Antibody
  • Pdpn Antibody
  • PDPN_HUMAN Antibody
  • Podoplanin Antibody
  • Podoplanin / gp36 Antibody
  • PSEC0003 Antibody
  • PSEC0025 Antibody
  • T1 alpha Antibody
  • T1 ALPHA GENE Antibody
  • T1-alpha Antibody
  • T1A Antibody
  • T1A 2 Antibody
  • TI1A Antibody
  • TIA 2 Antibody
  • TIA2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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