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Anti-POC1B Antibody

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产品名称: Anti-POC1B Antibody
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Anti-POC1B Antibody


Anti-POC1B Antibody  的详细介绍
Name: Anti-POC1B Antibody
See all POC1B primary antibodies
Description: Rabbit polyclonal antibody to POC1B.
Applications: WB
Dilutions: WB: 1:500 - 1:2000.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human POC1B.
Protein Length: 478
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).
Tissue Specificity: Expressed in the retina.
Involvement in Disease: Cone-rod dystrophy 20: A form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Sequence Similarities: Belongs to the WD repeat POC1 family.
Post-Translational Modification: Phosphorylated in mitotic cells that may be mediated by CDK1.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Cytoplasm > Cytoskeleton > Cilium basal body. Cytoplasm > Cytoskeleton > Spindle pole.

Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer.
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