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Anti-PNPLA2 Antibody

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产品名称: Anti-PNPLA2 Antibody
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Anti-PNPLA2 Antibody


Anti-PNPLA2 Antibody  的详细介绍
Name: Anti-PNPLA2 Antibody
See all PNPLA2 primary antibodies
Description: Rabbit polyclonal antibody to PNPLA2
Specificity: The antibody detects endogenous level of total PNPLA2 antibody.
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human PNPLA2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Tissue Specificity: Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).
Involvement in Disease: Neutral lipid storage disease with myopathy: Neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
Post-Translational Modification: Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation.
Cellular Location: Lipid droplet. Cell membrane.
Database Links:
  • Entrez Gene: 57104 Human
  • Entrez Gene: 66853 Mouse
  • Entrez Gene: 361676 Rat
  • Omim: 609059 Human
  • SwissProt: Q96AD5 Human
  • SwissProt: Q8BJ56 Mouse
  • SwissProt: P0C548 Rat
  • Unigene: 654697 Human
  • Unigene: 29998 Mouse
  • Unigene: 19196 Rat
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    Synonyms:
  • 1110001C14Rik Antibody
  • Adipose Triglyceride Lipase Antibody
  • ATGL Antibody
  • ATGL DESNUTRIN Antibody
  • Calcium independent phospholipase A2 Antibody
  • Calcium-independent phospholipase A2 Antibody
  • Desnutrin Antibody
  • EC 3.1.1.3 Antibody
  • FP17548 Antibody
  • IPLA2 zeta Antibody
  • IPLA2-zeta Antibody
  • Mutant patatin like phospholipase domain containing 2 Antibody
  • Patatin like phospholipase domain containing 2 Antibody
  • PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2 Antibody
  • Patatin-like phospholipase domain-containing protein 2 Antibody
  • PEDF R Antibody
  • PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA Antibody
  • Pigment epithelium derived factor Antibody
  • Pigment epithelium-derived factor Antibody
  • plpl Antibody
  • plpl2 Antibody
  • PLPL2_HUMAN Antibody
  • Pnpla2 Antibody
  • Transport secretion protein 2 Antibody
  • Transport secretion protein 2.2 Antibody
  • Transport-secretion protein 2 Antibody
  • Triglyceride hydrolase Antibody
  • TTS 2.2 Antibody
  • TTS2 Antibody
  • TTS2.2 Antibody
  • ZETA Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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