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Anti-PNP Antibody

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产品名称: Anti-PNP Antibody
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简单介绍

Anti-PNP Antibody


Anti-PNP Antibody  的详细介绍
Name: Anti-PNP Antibody
See all Nucleoside phosphorylase primary antibodies
Description: Goat polyclonal antibody to PNP.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human PNP (internal region).
Sequence: C-SGQNPLRGPNDE
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Tissue Specificity: Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
Involvement in Disease: Purine nucleoside phosphorylase deficiency: A disorder that interrupts both the catabolism of inosine into hypoxanthine and guanosine into guanine, and leads to the accumulation of guanosine, inosine, and their deoxified by-products. The main clinical presentation is recurrent infections due to severe T-cell immunodeficiency. Some patients also have neurologic impairment.
Sequence Similarities: Belongs to the PNP/MTAP phosphorylase family.
Cellular Location: Cytoplasm > Cytoskeleton. Cytoplasm.
Database Links:
  • Entrez Gene: 4860 Human
  • Omim: 164050 Human
  • SwissProt: P00491 Human
  • Unigene: 75514 Human
    		•
    Synonyms:
  • FLJ94043 Antibody
  • FLJ97288 Antibody
  • FLJ97312 Antibody
  • Inosine phosphorylase Antibody
  • Inosine-guanosine phosphorylase Antibody
  • MGC117396 Antibody
  • MGC125915 Antibody
  • MGC125916 Antibody
  • NP Antibody
  • Np1 Antibody
  • Nucleoside phosphorylase Antibody
  • PNP Antibody
  • Pnp1 Antibody
  • PNPH_HUMAN Antibody
  • PRO1837 Antibody
  • PUNP Antibody
  • Purine nucleoside orthophosphate ribosyltransferase Antibody
  • Purine nucleoside phosphorylase Antibody
  • Purine nucleoside phosphorylase 5a Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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