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Anti-SMARCA5 Antibody

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产品名称: Anti-SMARCA5 Antibody
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Anti-SMARCA5 Antibody


Anti-SMARCA5 Antibody  的详细介绍
Name: Anti-SMARCA5 Antibody
See all SMARCA5 primary antibodies
Description: Rabbit polyclonal antibody to SMARCA5
Specificity: The antibody detects endogenous level of total SMARCA5 protein.
Applications: WB, IHC, IF, IP, CHIP
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SMARCA5.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Tissue Specificity: Ubiquitously expressed.
Sequence Similarities: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 8467?Human
  • Entrez Gene: 93762?Mouse
  • Entrez Gene: 307766?Rat
  • Omim: 603375?Human
  • SwissProt: O60264?Human
  • SwissProt: Q91ZW3?Mouse
  • Unigene: 558422?Human
  • Unigene: 246803?Mouse
  • Unigene: 474173?Mouse
  • Unigene: 128772?Rat
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    Synonyms:
  • 4933427E24Rik Antibody
  • D030040M08Rik Antibody
  • D330027N15Rik Antibody
  • EC 3.6.1.- Antibody
  • hISWI Antibody
  • hSNF2H Antibody
  • ISWI Antibody
  • MommeD4 Antibody
  • SMARCA5 Antibody
  • SMCA5_HUMAN Antibody
  • SNF2H Antibody
  • Sucrose nonfermenting like 5 Antibody
  • Sucrose nonfermenting protein 2 homolog Antibody
  • Sucrose nonfermenting, yeast, homolog of Antibody
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Antibody
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 Antibody
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Antibody
  • WCRF135 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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