产品资料

Anti-SMAD2 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-SMAD2 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-SMAD2 Antibody


Anti-SMAD2 Antibody  的详细介绍
Name: Anti-SMAD2 Antibody
See all SMAD2 primary antibodies
Description: Goat polyclonal antibody to SMAD2.
Applications: ELISA, WB
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to Human SMAD2 (internal region).
Sequence: SEIWGLSTPNTIDC
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Sequence Similarities: Belongs to the dwarfin/SMAD family.
Post-Translational Modification: In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.
Cellular Location: Cytoplasm. Nucleus.

Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Database Links:
  • Entrez Gene: 4087 Human
  • Entrez Gene: 17126 Mouse
  • Omim: 601366 Human
  • SwissProt: Q15796 Human
  • SwissProt: Q62432 Mouse
  • Unigene: 12253 Human
  • Unigene: 705764 Human
  • Unigene: 152699 Mouse
  • Unigene: 391091 Mouse
    		•
    Synonyms:
  • Drosophila, homolog of, MADR2 Antibody
  • hMAD-2 Antibody
  • HsMAD2 Antibody
  • JV18 Antibody
  • JV18-1 Antibody
  • JV181 Antibody
  • MAD Antibody
  • MAD homolog 2 Antibody
  • MAD Related Protein 2 Antibody
  • Mad-related protein 2 Antibody
  • MADH2 Antibody
  • MADR2 Antibody
  • MGC22139 Antibody
  • MGC34440 Antibody
  • Mother against DPP homolog 2 Antibody
  • Mothers against decapentaplegic homolog 2 Antibody
  • Mothers against decapentaplegic, Drosophila, homolog of, 2 Antibody
  • Mothers against DPP homolog 2 Antibody
  • OTTHUMP00000163489 Antibody
  • Sma and Mad related protein 2 Antibody
  • Sma- and Mad-related protein 2 MAD Antibody
  • SMAD 2 Antibody
  • SMAD family member 2 Antibody
  • SMAD, mothers against DPP homolog 2 Antibody
  • Smad2 Antibody
  • SMAD2_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号