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Anti-Sirp α1 Antibody

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产品名称: Anti-Sirp α1 Antibody
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Anti-Sirp α1 Antibody


Anti-Sirp α1 Antibody  的详细介绍
Name: Anti-Sirp α1 Antibody
See all Sirp α1 primary antibodies
Description: Rabbit polyclonal antibody to Sirp α1
Specificity: The antibody detects endogenous levels of total Sirp α1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human SIRP-alpha1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Tissue Specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Post-Translational Modification: N-glycosylated.
Cellular Location: Membrane.
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