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Anti-SIGMAR1 Antibody

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产品名称: Anti-SIGMAR1 Antibody
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Anti-SIGMAR1 Antibody


Anti-SIGMAR1 Antibody  的详细介绍
Name: Anti-SIGMAR1 Antibody
See all SIGMAR1 primary antibodies
Description: Rabbit polyclonal antibody to SIGMAR1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:100 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SIGMAR1.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity).
Tissue Specificity: Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020).
Involvement in Disease: Amyotrophic lateral sclerosis 16, juvenile: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.

Distal spinal muscular atrophy, autosomal recessive, 2: An autosomal recessive neuromuscular disorder characterized by onset of distal muscle weakness and wasting affecting the lower and upper limbs in the first decade. There is no sensory involvement.
Sequence Similarities: Belongs to the ERG2 family.
Cellular Location: Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection > Growth cone. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density.

During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020). Enriched at cell-cell communication regions, growth cone and postsynaptic structures. Localization is modulated by ligand-binding. In motor neurons it is enriched at cholinergic postsynaptic densities (By similarity).
Database Links:
  • Entrez Gene: 10280?Human
  • Entrez Gene: 18391?Mouse
  • Entrez Gene: 29336?Rat
  • Omim: 601978?Human
  • SwissProt: Q99720?Human
  • SwissProt: O55242?Mouse
  • SwissProt: Q9R0C9?Rat
  • Unigene: 522087?Human
  • Unigene: 425181?Mouse
  • Unigene: 1129?Rat
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    Synonyms:
  • Aging associated gene 8 protein Antibody
  • Aging-associated gene 8 protein Antibody
  • AL024364 Antibody
  • hSigmaR1 Antibody
  • mSigmaR1 Antibody
  • opioid receptor, sigma 1 Antibody
  • opioid receptor, sigma 1 isoform 1 Antibody
  • RP23 167I12.6 Antibody
  • SGMR1_HUMAN Antibody
  • SIG 1R Antibody
  • SIG-1R Antibody
  • Sigma 1-type opioid receptor Antibody
  • Sigma non-opioid intracellular receptor 1 Antibody
  • sigma1 receptor Antibody
  • Sigma1-receptor Antibody
  • Sigma1-receptor/OPRS1 Antibody
  • Sigma1R Antibody
  • Sigmar1 Antibody
  • SR BP Antibody
  • SR-BP Antibody
  • SR31747 binding protein Antibody
  • SR31747-binding protein Antibody
  • SRBP Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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