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Anti-SHP-2 (Ab-542) Antibody

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产品名称: Anti-SHP-2 (Ab-542) Antibody
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Anti-SHP-2 (Ab-542) Antibody


Anti-SHP-2 (Ab-542) Antibody  的详细介绍
Name: Anti-SHP-2 (Ab-542) Antibody
See all SHP-2 primary antibodies
Description: Rabbit polyclonal antibody to SHP-2 (Ab-542)
Specificity: The antibody detects endogenous level of total SHP-2 protein.
Applications: WB, IHC, IF
Dilutions: Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:200
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around aa. 540~544 (H-E-Y-T-N) derived from Human SHP-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration: 1.0mg / ml
Predicted MW: 72kd
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Tissue Specificity: Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Involvement in Disease: LEOPARD syndrome 1: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness.

Noonan syndrome 1: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints.

Leukemia, juvenile myelomonocytic: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.

Metachondromatosis: A skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest.
Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification: Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 5781?Human
  • Entrez Gene: 19247?Mouse
  • Entrez Gene: 25622?Rat
  • Omim: 176876?Human
  • SwissProt: Q06124?Human
  • SwissProt: P35235?Mouse
  • SwissProt: P41499?Rat
  • Unigene: 506852?Human
  • Unigene: 474046?Mouse
  • Unigene: 8681?Mouse
  • Unigene: 98209?Rat
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    Synonyms:
  • BPTP3 Antibody
  • CFC Antibody
  • JMML Antibody
  • METCDS Antibody
  • MGC14433 Antibody
  • NS1 Antibody
  • OTTHUMP00000166107 Antibody
  • OTTHUMP00000166108 Antibody
  • Protein tyrosine phosphatase 2 Antibody
  • Protein tyrosine phosphatase 2C Antibody
  • Protein tyrosine phosphatase non receptor type 11 Antibody
  • Protein-tyrosine phosphatase 1D Antibody
  • Protein-tyrosine phosphatase 2C Antibody
  • PTN11_HUMAN Antibody
  • PTP-1D Antibody
  • PTP-2C Antibody
  • PTP1D Antibody
  • PTP2C Antibody
  • PTPN11 Antibody
  • SAP2 Antibody
  • SH-PTP2 Antibody
  • SH-PTP3 Antibody
  • SH2 domain containing protein tyrosine phosphatase 2 Antibody
  • SHP 2 Antibody
  • SHP-2 Antibody
  • SHP2 Antibody
  • SHPTP2 Antibody
  • SHPTP3 Antibody
  • Syp Antibody
  • Tyrosine-protein phosphatase non-receptor type 11 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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