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Anti-Shc1 (Phospho-Tyr427) Antibody

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产品名称: Anti-Shc1 (Phospho-Tyr427) Antibody
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Anti-Shc1 (Phospho-Tyr427) Antibody


Anti-Shc1 (Phospho-Tyr427) Antibody  的详细介绍
Name: Anti-Shc1 (Phospho-Tyr427) Antibody
See all Shc1 primary antibodies
Description: Rabbit polyclonal antibody to Shc1 (Phospho-Tyr427)
Specificity: The antibody detects endogenous level of Shc1 only when phosphorylated at tyrosine 427.
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N derived from Human Shc1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Tissue Specificity: Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Post-Translational Modification: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to FLT4 and KIT signaling. Isoform p46Shc and isoform p52Shc are phosphorylated on tyrosine residues of the Pro-rich domain. Isoform p66Shc is phosphorylated on Ser-36 by PRKCB upon treatment with insulin, hydrogen peroxide or irradiation with ultraviolet light (By similarity). Tyrosine phosphorylated in response to FLT3 signaling (By similarity). Tyrosine phosphorylated by activated PTK2B/PYK2 (By similarity). Tyrosine phosphorylated by ligand-activated ALK. Tyrosine phosphorylated by ligand-activated PDGFRB. Tyrosine phosphorylated by TEK/TIE2. May be tyrosine phosphorylated by activated PTK2/FAK1; tyrosine phosphorylation was seen in an astrocytoma biopsy, where PTK2/FAK1 kinase activity is high, but not in normal brain tissue. Isoform p52Shc dephosphorylation by PTPN2 may regulate interaction with GRB2.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 6464?Human
  • Omim: 600560?Human
  • SwissProt: P29353?Human
  • Unigene: 433795?Human
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    Synonyms:
  • FLJ26504 Antibody
  • p66 Antibody
  • p66SHC Antibody
  • SH2 domain protein C1 Antibody
  • SHC Antibody
  • SHC (Src homology 2 domain containing) transforming protein 1 Antibody
  • SHC 1 Antibody
  • SHC A Antibody
  • SHC adaptor protein 1 Antibody
  • SHC transforming protein Antibody
  • SHC transforming protein 1 Antibody
  • SHC-transforming protein 1 Antibody
  • SHC-transforming protein 3 Antibody
  • SHC-transforming protein A Antibody
  • SHC1 Antibody
  • SHC1_HUMAN Antibody
  • SHCA Antibody
  • Src homology 2 domain-containing-transforming protein C1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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