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Anti-SH3KBP1 Antibody

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产品名称: Anti-SH3KBP1 Antibody
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简单介绍

Anti-SH3KBP1 Antibody


Anti-SH3KBP1 Antibody  的详细介绍
Name: Anti-SH3KBP1 Antibody
See all SH3KBP1 primary antibodies
Description: Rabbit polyclonal antibody to SH3KBP1
Specificity: The antibody detects endogenous levels of total SH3KBP1 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human SH3-domain kinase binding protein 1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.6mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.
Tissue Specificity: Ubiquitously expressed. Also expressed in some cancer cell lines.
Post-Translational Modification: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasmic vesicle membrane. Cell junction > Synapse > Synaptosome. Cell junction > Focal adhesion.

Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403).
Database Links:
  • Entrez Gene: 30011?Human
  • Omim: 300374?Human
  • SwissProt: Q96B97?Human
  • Unigene: 726365?Human
    		•
    Synonyms:
  • c Cbl interacting protein Antibody
  • Cbl interacting protein Antibody
  • Cbl interacting protein of 85 kDa Antibody
  • Cbl-interacting protein of 85 kDa Antibody
  • CD2 binding protein 3 Antibody
  • CD2-binding protein 3 Antibody
  • CD2BP3 Antibody
  • CIN 85 Antibody
  • CIN85 Antibody
  • GIG 10 Antibody
  • GIG10 Antibody
  • HSB 1 Antibody
  • HSB-1 Antibody
  • HSB1 Antibody
  • Human Src family kinase binding protein 1 Antibody
  • Human Src family kinase-binding protein 1 Antibody
  • MIG 18 Antibody
  • MIG18 Antibody
  • Migration inducing gene 18 Antibody
  • Migration inducing gene 18 protein Antibody
  • SH3 domain kinase binding protein 1 Antibody
  • SH3 domain-containing kinase-binding protein 1 Antibody
  • SH3BP 1 Antibody
  • SH3K1_HUMAN Antibody
  • SH3KBP1 Antibody
  • Src family kinase binding protein 1 Antibody
  • src related kinase binding protein 1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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