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Anti-SH2D1A Antibody

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产品名称: Anti-SH2D1A Antibody
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简单介绍

Anti-SH2D1A Antibody


Anti-SH2D1A Antibody  的详细介绍
Name: Anti-SH2D1A Antibody
See all SH2D1A primary antibodies
Description: Goat polyclonal antibody to SH2D1A.
Applications: ELISA, WB, IP
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human SH2D1A (internal region).
Sequence: C-HKRYFRKIKN
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Tissue Specificity: Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
Involvement in Disease: Lymphoproliferative syndrome, X-linked, 1: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 4068 Human
  • Omim: 300490 Human
  • SwissProt: O60880 Human
  • Unigene: 349094 Human
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    Synonyms:
  • DSHP Antibody
  • Duncan disease SH2 protein Antibody
  • Duncan disease SH2-protein Antibody
  • EBVS Antibody
  • IMD5 Antibody
  • LYP Antibody
  • MTCP1 Antibody
  • SAP Antibody
  • SAP/SH2D1A Antibody
  • SH2 domain containing 1A Antibody
  • SH2 domain protein 1A Antibody
  • SH2 domain-containing protein 1A Antibody
  • SH21A_HUMAN Antibody
  • SH2D1A Antibody
  • SH2D1A/SAP Antibody
  • Signaling lymphocyte activation molecule associated protein Antibody
  • Signaling lymphocytic activation molecule-associated protein Antibody
  • SLAM associated protein Antibody
  • SLAM associated protein/SH2 domain protein 1A Antibody
  • SLAM-associated protein Antibody
  • T cell signal transduction molecule SAP Antibody
  • T-cell signal transduction molecule SAP Antibody
  • XLP Antibody
  • XLPD Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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