产品资料

Anti-SH2D1A Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-SH2D1A Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-SH2D1A Antibody


Anti-SH2D1A Antibody  的详细介绍
Name: Anti-SH2D1A Antibody
See all SH2D1A primary antibodies
Description: Rabbit polyclonal antibody to SH2D1A
Specificity: SH2D1A pAb detects endogenous levels of SH2D1A protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human SH2D1A.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 14 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Tissue Specificity: Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
Involvement in Disease: Lymphoproliferative syndrome, X-linked, 1: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 4068?Human
  • Entrez Gene: 20400?Mouse
  • Entrez Gene: 501502?Rat
  • Omim: 300490?Human
  • SwissProt: O60880?Human
  • SwissProt: O88890?Mouse
  • SwissProt: B2RZ59?Rat
  • Unigene: 349094?Human
  • Unigene: 441197?Mouse
  • Unigene: 12605?Rat
    		•
    Synonyms:
  • DSHP Antibody
  • Duncan disease SH2 protein Antibody
  • Duncan disease SH2-protein Antibody
  • EBVS Antibody
  • IMD5 Antibody
  • LYP Antibody
  • MTCP1 Antibody
  • SAP Antibody
  • SAP/SH2D1A Antibody
  • SH2 domain containing 1A Antibody
  • SH2 domain protein 1A Antibody
  • SH2 domain-containing protein 1A Antibody
  • SH21A_HUMAN Antibody
  • SH2D1A Antibody
  • SH2D1A/SAP Antibody
  • Signaling lymphocyte activation molecule associated protein Antibody
  • Signaling lymphocytic activation molecule-associated protein Antibody
  • SLAM associated protein Antibody
  • SLAM associated protein/SH2 domain protein 1A Antibody
  • SLAM-associated protein Antibody
  • T cell signal transduction molecule SAP Antibody
  • T-cell signal transduction molecule SAP Antibody
  • XLP Antibody
  • XLPD Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号