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Anti-SH2B1 Antibody

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产品名称: Anti-SH2B1 Antibody
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Anti-SH2B1 Antibody


Anti-SH2B1 Antibody  的详细介绍
Name: Anti-SH2B1 Antibody
See all SH2B1 primary antibodies
Description: Rabbit polyclonal antibody to SH2B1
Specificity: SH2B1 pAb detects endogenous levels of SH2B1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human SH2B1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~79 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential s for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity).
Tissue Specificity: Widely expressed with highest levels in skeletal muscle and ovary.
Sequence Similarities: Belongs to the SH2B adapter family.
Post-Translational Modification: Phosphorylated on tyrosine residues in response to receptor kinase stimulation. Phosphorylated by RET.
Cellular Location: Cytoplasm. Membrane. Nucleus.

Shuttles between the nucleus and the cytoplasm.
Database Links:
  • Entrez Gene: 25970?Human
  • Entrez Gene: 20399?Mouse
  • Entrez Gene: 89817?Rat
  • Omim: 608937?Human
  • SwissProt: Q9NRF2?Human
  • SwissProt: Q91ZM2?Mouse
  • SwissProt: Q62985?Rat
  • Unigene: 15744?Human
  • Unigene: 8538?Mouse
  • Unigene: 11069?Rat
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    Synonyms:
  • DKFZp547G1110 Antibody
  • FLJ30542 Antibody
  • KIAA1299 Antibody
  • PH and SH2 domain-containing signaling mediator Antibody
  • Pro-rich Antibody
  • Pro-rich, PH and SH2 domain-containing signaling mediator Antibody
  • PSM Antibody
  • SH2 B Antibody
  • SH2 domain-containing protein 1B Antibody
  • SH2 domain-containing putative adapter SH2-B Antibody
  • SH2-B signaling protein Antibody
  • SH2B Antibody
  • SH2B adapter protein 1 Antibody
  • SH2B adaptor protein 1 Antibody
  • SH2B1 Antibody
  • SH2B1 protein Antibody
  • SH2B1_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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