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Anti-SGK3 Antibody

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产品名称: Anti-SGK3 Antibody
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Anti-SGK3 Antibody


Anti-SGK3 Antibody  的详细介绍
Name: Anti-SGK3 Antibody
See all SGK3 primary antibodies
Description: Chicken polyclonal antibody to SGK3
Applications: CM, ELISA, IC, IF, IHC, IP, WB
Dilutions: Confocal Microscopy: 1:100; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:100; Immunofluorescence: 1:100; Immunohistochemistry: 1:100; Immunoprecipitation: 1:200; Western Blot: 1:498
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 440-490 on human Sgk3 protein.
Host: Chicken
Clonality: Polyclonal
Conjugate: Unconjugated
Concentration: 0.6 μg/μl in antibody stabilization buffer
Storage: -20?C for long term storage
Function: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.
Tissue Specificity: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Post-Translational Modification: Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
Cellular Location: Cytoplasmic vesicle. Early endosome. Recycling endosome.

Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
Database Links:
  • Entrez Gene: 100533105?Human
  • Entrez Gene: 23678?Human
  • Entrez Gene: 170755?Mouse
  • Entrez Gene: 171498?Rat
  • Omim: 607591?Human
  • SwissProt: Q96BR1?Human
  • SwissProt: Q9ERE3?Mouse
  • SwissProt: Q8R4V0?Rat
  • Unigene: 613417?Human
  • Unigene: 336410?Mouse
  • Unigene: 195351?Rat
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    Synonyms:
  • CISK Antibody
  • Cytokine independent survival kinase Antibody
  • DKFZp781N0293 Antibody
  • Serine/threonine protein kinase Sgk3 Antibody
  • Serine/threonine-protein kinase Sgk3 Antibody
  • Serum/glucocorticoid regulated kinase 3 Antibody
  • Serum/glucocorticoid regulated kinase family member 3 Antibody
  • Serum/glucocorticoid regulated kinase like Antibody
  • Serum/glucocorticoid-regulated kinase 3 Antibody
  • Serum/glucocorticoid-regulated kinase-like Antibody
  • SGK 2 Antibody
  • SGK 3 Antibody
  • SGK2 Antibody
  • SGK3 Antibody
  • SGK3_HUMAN Antibody
  • SGKL Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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