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Anti-SFRS1 Antibody

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产品名称: Anti-SFRS1 Antibody
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简单介绍

Anti-SFRS1 Antibody


Anti-SFRS1 Antibody  的详细介绍
Name: Anti-SFRS1 Antibody
See all SFRS1 primary antibodies
Description: Rabbit polyclonal antibody to SFRS1
Specificity: SFRS1 pAb detects endogenous levels of SFRS1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human SFRS1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 27 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.
Sequence Similarities: Belongs to the splicing factor SR family.
Post-Translational Modification: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed.
Cellular Location: Cytoplasm. Nucleus speckle.

In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Database Links:
  • Entrez Gene: 6426?Human
  • Entrez Gene: 110809?Mouse
  • Entrez Gene: 689890?Rat
  • Omim: 600812?Human
  • SwissProt: Q07955?Human
  • SwissProt: Q6PDM2?Mouse
  • Unigene: 68714?Human
  • Unigene: 391719?Mouse
  • Unigene: 84878?Rat
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    Synonyms:
  • Alternative splicing factor 1 Antibody
  • Alternative-splicing factor 1 Antibody
  • arginine/serine-rich 1 Antibody
  • ASF Antibody
  • ASF 1 Antibody
  • ASF-1 Antibody
  • ASF1 Antibody
  • FLJ53078 Antibody
  • MGC5228 Antibody
  • P33 subunit Antibody
  • Pre mRNA splicing factor SF2 P33 subunit Antibody
  • pre-mRNA-splicing factor SF2 Antibody
  • Serine/arginine-rich splicing factor 1 Antibody
  • SF2 Antibody
  • SF2P33 Antibody
  • SFRS1 Antibody
  • Splicing factor Antibody
  • Splicing factor 2 Antibody
  • Splicing factor 2 alternate splicing factor Antibody
  • Splicing factor arginine/serine rich 1 Antibody
  • SR Splicing factor 1 Antibody
  • SRp30a Antibody
  • srsf1 Antibody
  • SRSF1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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