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Anti-SFRP4 Antibody

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产品名称: Anti-SFRP4 Antibody
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Anti-SFRP4 Antibody


Anti-SFRP4 Antibody  的详细介绍
Name: Anti-SFRP4 Antibody
See all SFRP4 primary antibodies
Description: Rabbit polyclonal antibody to SFRP4
Specificity: SFRP4 polyclonal antibody detects endogenous levels of SFRP4 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human SFRP4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 40 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of ***** uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Tissue Specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Involvement in Disease: Pyle disease: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.
Cellular Location: Secreted.

Cytoplasmic in ovarian tumor cells.
Database Links:
  • Entrez Gene: 6424?Human
  • Entrez Gene: 20379?Mouse
  • Entrez Gene: 89803?Rat
  • Omim: 606570?Human
  • SwissProt: Q6FHJ7?Human
  • SwissProt: Q9Z1N6?Mouse
  • SwissProt: Q9JLS4?Rat
  • Unigene: 658169?Human
  • Unigene: 10788?Rat
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    Synonyms:
  • Frizzled protein Antibody
  • Frizzled protein human endometrium Antibody
  • FRP 4 Antibody
  • FRP4 Antibody
  • FrpHE Antibody
  • human endometrium Antibody
  • PYL Antibody
  • Secreted frizzled-related protein 4 Antibody
  • sFRP-4 Antibody
  • SFRP4 Antibody
  • SFRP4_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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