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Anti-SETMAR Antibody

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产品名称: Anti-SETMAR Antibody
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简单介绍

Anti-SETMAR Antibody


Anti-SETMAR Antibody  的详细介绍
Name: Anti-SETMAR Antibody
See all SETMAR primary antibodies
Description: Rabbit polyclonal antibody to SETMAR
Specificity: The antibody detects endogenous levels of total SETMAR protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein of human SETMAR
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).
Tissue Specificity: Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
Sequence Similarities: In the N-terminal section; belongs to the class V-like SAM-binding methyltransferase superfamily.
Post-Translational Modification: Methylated. Methylation regulates activity in DNA decatenation.
Cellular Location: Nucleus. Chromosome.

Recruited on damaged DNA at sites of double-strand breaks.
Database Links:
  • Entrez Gene: 6419?Human
  • Omim: 609834?Human
  • SwissProt: Q53H47?Human
  • Unigene: 475300?Human
  • Unigene: 716054?Human
    		•
    Synonyms:
  • Histone lysine N methyltransferase Antibody
  • Histone lysine N methyltransferase SETMAR Antibody
  • Hsmar 1 Antibody
  • Hsmar1 Antibody
  • Mariner transposase Hsmar1 Antibody
  • Metnase Antibody
  • SET domain and mariner transposase fusion Antibody
  • SET domain and mariner transposase fusion gene Antibody
  • SET domain and mariner transposase fusion gene containing protein Antibody
  • SET domain and mariner transposase fusion gene-containing protein Antibody
  • SETMAR Antibody
  • SETMR_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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