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Anti-SET Antibody

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产品名称: Anti-SET Antibody
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简单介绍

Anti-SET Antibody


Anti-SET Antibody  的详细介绍
Name: Anti-SET Antibody
See all SET primary antibodies
Description: Rabbit polyclonal antibody to SET
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 11 of SET
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
Tissue Specificity: Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor.
Sequence Similarities: Belongs to the nucleosome assembly protein (NAP) family.
Post-Translational Modification: Isoform 2 is phosphorylated on Ser-15 and Thr-23.
Cellular Location: Cytoplasm > Cytosol. Endoplasmic reticulum. Nucleus > Nucleoplasm.

In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
Database Links:
  • Entrez Gene: 6418?Human
  • Omim: 600960?Human
  • SwissProt: Q01105?Human
  • Unigene: 436687?Human
  • Unigene: 596814?Human
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    Synonyms:
  • 2PP2A Antibody
  • HLA DR associated protein II Antibody
  • HLA-DR-associated protein II Antibody
  • I 2PP2A Antibody
  • I-2PP2A Antibody
  • I2PP2A Antibody
  • IGAAD Antibody
  • Inhibitor of granzyme A activated DNase Antibody
  • Inhibitor of granzyme A-activated DNase Antibody
  • Inhibitor of GzmA-activated DNase Antibody
  • inhibitor-2 of protein phosphatase-2A Antibody
  • IPP2A2 Antibody
  • PHAPII Antibody
  • Phosphatase 2A inhibitor I2PP2A Antibody
  • protein phosphatase type 2A inhibitor Antibody
  • Protein SET Antibody
  • SET Antibody
  • SET nuclear oncogene Antibody
  • SET translocation Antibody
  • SET translocation (myeloid leukemia-associated) Antibody
  • SET_HUMAN Antibody
  • TAF I Antibody
  • TAF IBETA Antibody
  • TAF-I Antibody
  • TAFI Antibody
  • Template activating factor I Antibody
  • Template-activating factor I Antibody
  • Template-Activating Factor-I, chromatin remodelling factor Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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