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Anti-SERPINC1 Antibody

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产品名称: Anti-SERPINC1 Antibody
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Anti-SERPINC1 Antibody


Anti-SERPINC1 Antibody  的详细介绍
Name: Anti-SERPINC1 Antibody
See all SERPINC1 primary antibodies
Description: Rabbit polyclonal antibody to SERPINC1
Specificity: SERPINC1 pAb detects endogenous levels of SERPINC1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human SERPINC1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 53 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Tissue Specificity: Found in plasma.
Involvement in Disease: Antithrombin III deficiency: An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: Phosphorylated by FAM20C in the extracellular medium.
Cellular Location: Secreted > Extracellular space.
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