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Anti-SERPINB6 Antibody

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产品名称: Anti-SERPINB6 Antibody
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简单介绍

Anti-SERPINB6 Antibody


Anti-SERPINB6 Antibody  的详细介绍
Name: Anti-SERPINB6 Antibody
See all SERPINB6 primary antibodies
Description: Rabbit polyclonal antibody to SERPINB6
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 66 and 283 of SERPINB6
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Tissue Specificity: Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
Involvement in Disease: Deafness, autosomal recessive, 91: A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
Sequence Similarities: Belongs to the serpin family. Ov-serpin subfamily.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 5269?Human
  • Omim: 173321?Human
  • SwissProt: P35237?Human
  • Unigene: 519523?Human
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    Synonyms:
  • CAP Antibody
  • Cytoplasmic antiproteinase Antibody
  • Peptidase inhibitor 6 Antibody
  • PI-6 Antibody
  • PI6 Antibody
  • Placental thrombin inhibitor Antibody
  • Protease inhibitor 6 (placental thrombin inhibitor) Antibody
  • PTI Antibody
  • Serpin B6 Antibody
  • SerpinB6 Antibody
  • SPB6_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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