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Anti-SERPINA1 Antibody

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产品名称: Anti-SERPINA1 Antibody
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简单介绍

Anti-SERPINA1 Antibody


Anti-SERPINA1 Antibody  的详细介绍
Name: Anti-SERPINA1 Antibody
See all SERPINA1 primary antibodies
Description: Rabbit polyclonal antibody to SERPINA1.
Applications: WB
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human
Immunogen: Recombinant protein of human SERPINA1.
Protein Length: 418
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Tissue Specificity: Ubiquitous. Expressed in leukocytes and plasma.
Involvement in Disease: Alpha-1-antitrypsin deficiency: A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and *****s, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant.
Cellular Location: Secreted. Endoplasmic reticulum.

The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.
Database Links:
  • Entrez Gene: 5265?Human
  • Omim: 107400?Human
  • SwissProt: P01009?Human
  • Unigene: 525557?Human
    		•
    Synonyms:
  • A1A Antibody
  • A1AT Antibody
  • A1AT_HUMAN Antibody
  • AAT Antibody
  • Alpha 1 antiproteinase Antibody
  • alpha 1 Antitrypsin Antibody
  • Alpha 1 antitrypsin null Antibody
  • Alpha 1 protease inhibitor Antibody
  • Alpha-1 protease inhibitor Antibody
  • Alpha-1-antiproteinase Antibody
  • alpha1 proteinase inhibitor Antibody
  • Alpha1AT Antibody
  • Dom1 Antibody
  • PI Antibody
  • PI1 Antibody
  • PRO2275 Antibody
  • Serine (or cysteine) proteinase inhibitor clade A member 1 Antibody
  • Serine protease inhibitor 1-1 Antibody
  • Serine protease inhibitor A1a Antibody
  • Serpin A1 Antibody
  • Serpin A1a Antibody
  • Serpin peptidase inhibitor clade A member 1 Antibody
  • Serpina1 Antibody
  • Short peptide from AAT Antibody
  • SPAAT Antibody
  • Spi1-1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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