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Anti-SENP1 (D2) Antibody

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产品名称: Anti-SENP1 (D2) Antibody
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Anti-SENP1 (D2) Antibody


Anti-SENP1 (D2) Antibody  的详细介绍
Name: Anti-SENP1 (D2) Antibody
See all SENP1 primary antibodies
Description: Rabbit polyclonal antibody to SENP1 (D2)
Specificity: SENP1 (D2) pAb detects endogenous levels of SENP1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to the N-terminual of Human SENP1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 73 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Tissue Specificity: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Sequence Similarities: Belongs to the peptidase C48 family.
Cellular Location: Nucleus. Cytoplasm.

Shuttles between cytoplasm and nucleus.
Database Links:
  • Entrez Gene: 29843?Human
  • Entrez Gene: 223870?Mouse
  • Omim: 612157?Human
  • SwissProt: Q9P0U3?Human
  • SwissProt: P59110?Mouse
  • Unigene: 603289?Human
  • Unigene: 384023?Mouse
    		•
    Synonyms:
  • SENP 1 Antibody
  • SENP1 Antibody
  • SENP1_HUMAN Antibody
  • Sentrin specific protease 1 Antibody
  • Sentrin-specific protease 1 Antibody
  • Sentrin/SUMO specific protease Antibody
  • Sentrin/SUMO specific protease 1 Antibody
  • Sentrin/SUMO specific protease SENP 1 Antibody
  • Sentrin/SUMO specific protease SENP1 Antibody
  • Sentrin/SUMO-specific protease SENP1 Antibody
  • SUMO1/sentrin specific peptidase 1 Antibody
  • SUMO1/sentrin specific protease 1 Antibody
  • SuPr 2 Antibody
  • SuPr2 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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