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Anti-SEK1 / MKK4 (Phospho-Ser80) Antibody

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产品名称: Anti-SEK1 / MKK4 (Phospho-Ser80) Antibody
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Anti-SEK1 / MKK4 (Phospho-Ser80) Antibody


Anti-SEK1 / MKK4 (Phospho-Ser80) Antibody  的详细介绍
Name: Anti-SEK1 / MKK4 (Phospho-Ser80) Antibody
See all SEK1 primary antibodies
Description: Rabbit polyclonal antibody to SEK1 / MKK4 (Phospho-Ser80)
Specificity: The antibody detects endogenous level of SEK1 / MKK4 only when phosphorylated at serine 80.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of serine 80 (T-H-S(p)-I-E) derived from Human SEK1 / MKK4.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Tissue Specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Post-Translational Modification: Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 6416?Human
  • Entrez Gene: 26398?Mouse
  • Entrez Gene: 287398?Rat
  • Omim: 601335?Human
  • SwissProt: P45985?Human
  • SwissProt: P47809?Mouse
  • Unigene: 514681?Human
  • Unigene: 412922?Mouse
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    Synonyms:
  • c Jun N terminal kinase kinase 1 Antibody
  • C-JUN N-terminal kinase kinase 1 Antibody
  • Dual specificity mitogen activated protein kinase kinase 4 Antibody
  • Dual specificity mitogen-activated protein kinase kinase 4 Antibody
  • JNK Activated Kinase 1 Antibody
  • JNK activating kinase 1 Antibody
  • JNK-activating kinase 1 Antibody
  • JNKK Antibody
  • JNKK1 Antibody
  • MAP kinase kinase 4 Antibody
  • Map2k4 Antibody
  • MAPK ERK kinase 4 Antibody
  • MAPK/ERK kinase 4 Antibody
  • MAPKK 4 Antibody
  • MAPKK4 Antibody
  • MEK 4 Antibody
  • MEK4 Antibody
  • Mitogen activated protein kinase kinase 4 Antibody
  • MKK 4 Antibody
  • MKK4 Antibody
  • MP2K4_HUMAN Antibody
  • PRKMK4 Antibody
  • SAPK ERK kinase 1 Antibody
  • SAPK/ERK kinase 1 Antibody
  • SAPKK 1 Antibody
  • SAPKK1 Antibody
  • SEK1 Antibody
  • SERK1 Antibody
  • SKK1 Antibody
  • Stress activated protein kinase kinase 1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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