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Anti-SDHB Antibody

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产品名称: Anti-SDHB Antibody
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Anti-SDHB Antibody


Anti-SDHB Antibody  的详细介绍
Name: Anti-SDHB Antibody
See all SDHB primary antibodies
Description: Goat polyclonal antibody to SDHB.
Applications: ELISA, WB, IHC, EIA
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human SDHB (C terminal).
Sequence: C-ATYKEKKASV
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 μg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Involvement in Disease: Pheochromocytoma: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.

Paragangliomas 4: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.

Paraganglioma and gastric stromal sarcoma: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.

Cowden syndrome 2: A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS2 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Cellular Location: Mitochondrion inner membrane.
Database Links:
  • Entrez Gene: 6390?Human
  • Omim: 185470?Human
  • SwissProt: P21912?Human
  • Unigene: 465924?Human
    		•
    Synonyms:
  • CWS2 Antibody
  • DHSB_HUMAN Antibody
  • FLJ92337 Antibody
  • Ip Antibody
  • Iron sulfur subunit Antibody
  • Iron sulfur subunit of complex II Antibody
  • Iron-sulfur subunit of complex II Antibody
  • mitochondrial Antibody
  • PGL 4 Antibody
  • PGL4 Antibody
  • SDH Antibody
  • SDH 1 Antibody
  • SDH1 Antibody
  • SDH2 Antibody
  • SDH2, homolog of Antibody
  • SDHB Antibody
  • SDHIP Antibody
  • Succinate Dehydrogenase 1 Iron Sulfur Subunit Antibody
  • Succinate Dehydrogenase 2, S. cerevisiae, homolog of Antibody
  • Succinate dehydrogenase complex iron sulfur subunit B Antibody
  • Succinate dehydrogenase complex subunit B iron sulfur Antibody
  • Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein Antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Antibody
  • Succinate dehydrogenase iron sulfur protein Antibody
  • Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial Antibody
  • Succinate dehydrogenase [ubiquinone] iron sulfur subunit Antibody
  • Succinate dehydrogenase [ubiquinone] iron-sulfur subunit Antibody
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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