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Anti-SDCBP Antibody

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产品名称: Anti-SDCBP Antibody
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Anti-SDCBP Antibody


Anti-SDCBP Antibody  的详细介绍
Name: Anti-SDCBP Antibody
See all SDCBP primary antibodies
Description: Rabbit polyclonal antibody to SDCBP
Specificity: The antibody detects endogenous levels of total SDCBP protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Full length fusion protein of human SDCBP
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2.2mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Tissue Specificity: Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In ***** highest expression in heart and placenta.
Post-Translational Modification: Phosphorylated on tyrosine residues.
Cellular Location: Cell junction > Focal adhesion. Cell junction > Adherens junction. Cell membrane. Endoplasmic reticulum membrane. Nucleus. Melanosome. Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Secreted > Exosome. Membrane raft.

Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966).
Database Links:
  • Entrez Gene: 6386?Human
  • Omim: 602217?Human
  • SwissProt: O00560?Human
  • Unigene: 200804?Human
    		•
    Synonyms:
  • MDA-9 Antibody
  • MDA9 Antibody
  • Melanoma differentiation-associated protein 9 Antibody
  • Pro-TGF-alpha cytoplasmic domain-interacting protein 18 Antibody
  • Scaffold protein Pbp1 Antibody
  • SDCB1_HUMAN Antibody
  • SDCBP Antibody
  • ST1 Antibody
  • SYCL Antibody
  • Syndecan binding protein (syntenin) Antibody
  • Syndecan binding protein 1 Antibody
  • Syndecan-binding protein 1 Antibody
  • Syntenin Antibody
  • Syntenin 1 Antibody
  • Syntenin-1 Antibody
  • TACIP18 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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