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Anti-SCO1 Antibody

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产品名称: Anti-SCO1 Antibody
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简单介绍

Anti-SCO1 Antibody


Anti-SCO1 Antibody  的详细介绍
Name: Anti-SCO1 Antibody
See all SCO1 primary antibodies
Description: Rabbit polyclonal antibody to SCO1.
Applications: WB, IHC
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SCO1.
Protein Length: 301
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
Tissue Specificity: Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Involvement in Disease: Mitochondrial complex IV deficiency: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
Sequence Similarities: Belongs to the SCO1/2 family.
Cellular Location: Mitochondrion.
Database Links:
  • Entrez Gene: 6341?Human
  • Entrez Gene: 52892?Mouse
  • Entrez Gene: 497930?Rat
  • Omim: 603644?Human
  • SwissProt: O75880?Human
  • SwissProt: Q5SUC9?Mouse
  • Unigene: 14511?Human
  • Unigene: 129731?Mouse
  • Unigene: 473182?Mouse
  • Unigene: 203819?Rat
    		•
    Synonyms:
  • Cytochrome oxidase deficient homolog Antibody
  • Cytochrome oxidase deficient homolog 1 Antibody
  • Protein SCO1 homolog mitochondrial Antibody
  • Protein SCO1 homolog, mitochondrial Antibody
  • SCO (cytochrome oxidase deficient yeast) homolog 1 Antibody
  • SCO cytochrome oxidase deficient homolog 1 Antibody
  • SCO cytochrome oxidase deficient homolog 1 (yeast) Antibody
  • SCO1 Antibody
  • SCO1_HUMAN Antibody
  • SCOD1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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