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Anti-SATB1 Antibody

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Anti-SATB1 Antibody


Anti-SATB1 Antibody  的详细介绍
Name: Anti-SATB1 Antibody
See all SATB1 primary antibodies
Description: Rabbit polyclonal antibody to SATB1
Specificity: The antibody detects endogenous level of total SATB1 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SATB1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-s provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
Tissue Specificity: Expressed predominantly in thymus.
Sequence Similarities: Belongs to the CUT homeobox family.
Post-Translational Modification: Sumoylated. Sumoylation promotes cleavage by caspases.
Cellular Location: Nucleus matrix. Nucleus > PML body.

Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).
Database Links:
  • Entrez Gene: 6304?Human
  • Entrez Gene: 20230?Mouse
  • Entrez Gene: 316164?Rat
  • Omim: 602075?Human
  • SwissProt: Q01826?Human
  • SwissProt: Q60611?Mouse
  • Unigene: 517717?Human
  • Unigene: 311655?Mouse
  • Unigene: 233782?Rat
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    Synonyms:
  • DNA binding protein SATB1 Antibody
  • DNA-binding protein SATB1 Antibody
  • SATB homeobox 1 Antibody
  • SATB1 Antibody
  • SATB1_HUMAN Antibody
  • Special AT rich sequence binding protein 1 Antibody
  • Special AT rich sequence binding protein 1 (binds to nuclear matrix/scaffold associating DNA) Antibody
  • Special AT-rich sequence-binding protein 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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