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Anti-SAP18 Antibody

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产品名称: Anti-SAP18 Antibody
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Anti-SAP18 Antibody


Anti-SAP18 Antibody  的详细介绍
Name: Anti-SAP18 Antibody
See all SAP18 primary antibodies
Description: Rabbit polyclonal antibody to SAP18.
Applications: WB, IHC
Dilutions: WB: 1:200 - 1:2000, IHC: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human SAP18.
Protein Length: 153 (172)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Tissue Specificity: Ubiquitous.
Sequence Similarities: Belongs to the SAP18 family.
Cellular Location: Nucleus. Cytoplasm. Nucleus speckle.

Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198).
Database Links:
  • Entrez Gene: 10284?Human
  • Entrez Gene: 20220?Mouse
  • Entrez Gene: 290284?Rat
  • Omim: 602949?Human
  • SwissProt: O00422?Human
  • SwissProt: O55128?Mouse
  • Unigene: 524899?Human
  • Unigene: 30173?Mouse
  • Unigene: 344671?Mouse
  • Unigene: 74373?Rat
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    Synonyms:
  • 18 kDa Sin3-associated polypeptide Antibody
  • 2HOR0202 Antibody
  • Cell growth-inhibiting gene 38 protein Antibody
  • Histone deacetylase complex subunit SAP18 Antibody
  • SAP18 Antibody
  • SAP18_HUMAN Antibody
  • Sin3-associated polypeptide p18 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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