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Anti-S100A12 Antibody

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产品名称: Anti-S100A12 Antibody
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Anti-S100A12 Antibody


Anti-S100A12 Antibody  的详细介绍
Name: Anti-S100A12 Antibody
See all S100A12 primary antibodies
Description: Rabbit polyclonal antibody to S100A12
Specificity: S100A12 pAb detects endogenous levels of S100A12 protein.
Applications: WB, IHC, IF
Reactivity: Human
Immunogen: Recombinant full length Human S100A12.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~10 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Tissue Specificity: Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.
Sequence Similarities: Belongs to the S-100 family.
Cellular Location: Secreted. Cytoplasm. Cytoplasm > Cytoskeleton. Cell membrane.

Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Database Links:
  • Entrez Gene: 6283?Human
  • Omim: 603112?Human
  • SwissProt: P80511?Human
  • Unigene: 19413?Human
    		•
    Synonyms:
  • CAAF1 Antibody
  • CAGC Antibody
  • Calcitermin Antibody
  • Calcium-binding protein in amniotic fluid 1 Antibody
  • Calgranulin C Antibody
  • Calgranulin-C Antibody
  • Calgranulin-related protein Antibody
  • CGRP Antibody
  • EN RAGE Antibody
  • EN-RAGE Antibody
  • ENRAGE Antibody
  • Extracellular newly identified RAGE-binding protein Antibody
  • migration inhibitory factor-related protein 6 Antibody
  • MRP6 Antibody
  • Neutrophil S100 protein Antibody
  • p6 Antibody
  • Protein S100 A12 Antibody
  • S100 calcium binding protein A12 Antibody
  • S100 calcium-binding protein A12 Antibody
  • S100 calcium-binding protein A12 (calgranulin C) Antibody
  • S100A12 Antibody
  • S10AC_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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