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Anti-RUNX1 (T270) Antibody

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产品名称: Anti-RUNX1 (T270) Antibody
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Anti-RUNX1 (T270) Antibody


Anti-RUNX1 (T270) Antibody  的详细介绍
Name: Anti-RUNX1 (T270) Antibody
See all RUNX1 primary antibodies
Description: Rabbit polyclonal antibody to RUNX1 (T270)
Specificity: RUNX1 (T270) pAb detects endogenous levels of RUNX1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human RUNX1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 55 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
Tissue Specificity: Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
Involvement in Disease: Familial platelet disorder with associated myeloid malignancy: Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Post-Translational Modification: Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 861?Human
  • Entrez Gene: 12394?Mouse
  • Entrez Gene: 50662?Rat
  • Omim: 151385?Human
  • SwissProt: Q01196?Human
  • SwissProt: Q03347?Mouse
  • SwissProt: Q63046?Rat
  • Unigene: 149261?Human
  • Unigene: 612648?Human
  • Unigene: 4081?Mouse
  • Unigene: 470227?Mouse
  • Unigene: 11201?Rat
    		•
    Synonyms:
  • Acute myeloid leukemia 1 Antibody
  • Acute myeloid leukemia 1 protein Antibody
  • alpha subunit core binding factor Antibody
  • AML 1 Antibody
  • AML1 Antibody
  • AML1 EVI 1 Antibody
  • AML1 EVI 1 fusion protein Antibody
  • Aml1 oncogene Antibody
  • AMLCR 1 Antibody
  • AMLCR1 Antibody
  • CBF alpha 2 Antibody
  • CBF-alpha-2 Antibody
  • CBFA 2 Antibody
  • CBFA2 Antibody
  • Core binding factor alpha 2 subunit Antibody
  • Core binding factor runt domain alpha subunit 2 Antibody
  • Core-binding factor subunit alpha-2 Antibody
  • EVI 1 Antibody
  • EVI1 Antibody
  • HGNC Antibody
  • Oncogene AML 1 Antibody
  • Oncogene AML-1 Antibody
  • OTTHUMP00000108696 Antibody
  • OTTHUMP00000108697 Antibody
  • OTTHUMP00000108699 Antibody
  • OTTHUMP00000108700 Antibody
  • OTTHUMP00000108702 Antibody
  • PEA2 alpha B Antibody
  • PEA2-alpha B Antibody
  • PEBP2 alpha B Antibody
  • PEBP2-alpha B Antibody
  • PEBP2A2 Antibody
  • PEBP2aB Antibody
  • Polyomavirus enhancer binding protein 2 alpha B subunit Antibody
  • Polyomavirus enhancer-binding protein 2 alpha B subunit Antibody
  • Run1 Antibody
  • Runt related transcription factor 1 Antibody
  • Runt-related transcription factor 1 Antibody
  • RUNX 1 Antibody
  • Runx1 Antibody
  • RUNX1 / AML1 Antibody
  • RUNX1_HUMAN Antibody
  • SL3 3 enhancer factor 1 alpha B subunit Antibody
  • SL3-3 enhancer factor 1 alpha B subunit Antibody
  • SL3/AKV core binding factor alpha B subunit Antibody
  • SL3/AKV core-binding factor alpha B subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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