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Anti-RPS3 Antibody

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产品名称: Anti-RPS3 Antibody
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简单介绍

Anti-RPS3 Antibody


Anti-RPS3 Antibody  的详细介绍
Name: Anti-RPS3 Antibody
See all RPS3 primary antibodies
Description: Rabbit polyclonal antibody to RPS3
Specificity: RPS3 pAb detects endogenous levels of RPS3 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human RPS3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~26 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).
Sequence Similarities: Belongs to the ribosomal protein S3P family.
Post-Translational Modification: Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.
Cellular Location: Cytoplasm. Nucleus. Nucleus > Nucleolus. Mitochondrion inner membrane. Cytoplasm > Cytoskeleton > Spindle.

In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661).
Database Links:
  • Entrez Gene: 6188?Human
  • Entrez Gene: 27050?Mouse
  • Entrez Gene: 140654?Rat
  • Omim: 600454?Human
  • SwissProt: P23396?Human
  • SwissProt: P62908?Mouse
  • SwissProt: P62909?Rat
  • Unigene: 546286?Human
  • Unigene: 236868?Mouse
  • Unigene: 127805?Rat
    		•
    Synonyms:
  • 40S ribosomal protein S3 Antibody
  • fb13d09 Antibody
  • FLJ26283 Antibody
  • FLJ27450 Antibody
  • IMR 90 ribosomal protein S3 Antibody
  • MGC56088 Antibody
  • MGC87870 Antibody
  • OTTHUMP00000229804 Antibody
  • OTTHUMP00000229805 Antibody
  • OTTHUMP00000229874 Antibody
  • OTTHUMP00000229877 Antibody
  • OTTHUMP00000229878 Antibody
  • OTTHUMP00000229879 Antibody
  • OTTHUMP00000229880 Antibody
  • OTTHUMP00000229882 Antibody
  • OTTHUMP00000229883 Antibody
  • OTTHUMP00000229886 Antibody
  • Ribosomal protein S3 Antibody
  • RPS3 Antibody
  • RS3_HUMAN Antibody
  • S3 Antibody
  • wu:fb13d09 Antibody
  • zgc:56088 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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