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Antibodies
Anti-WTAP Antibody
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产品名称:
Anti-WTAP Antibody
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简单介绍
Anti-WTAP
Antibody
Anti-WTAP Antibody
的详细介绍
Overview
Name:
Anti-WTAP
Antibody
See all WTAP primary antibodies
Description:
Rabbit polyclonal antibody to WTAP
Specificity:
The antibody detects endogenous levels of total WTAPv protein.
Applications:
WB
Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from C-terminal of human WTAP.
Host:
Rabbit
Clonality:
Polyclonal
Conjugate:
Unconjugated
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:
1.0mg / ml
Formulation:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:
Store at -20˚C
Target
Function:
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
Tissue Specificity:
Ubiquitously expressed.
Sequence Similarities:
Belongs to the fl(2)d family.
Cellular Location:
Nucleus > Nucleoplasm. Nucleus speckle.
Database Links:
Entrez Gene: 9589 Human
Entrez Gene: 60532 Mouse
Omim: 605442 Human
SwissProt: Q15007 Human
SwissProt: Q9ER69 Mouse
Unigene: 446091 Human
Unigene: 275521 Mouse
Synonyms:
DKFZp686F20131 Antibody
Female-lethal(2)D homolog Antibody
FL2D_HUMAN Antibody
hFL(2)D Antibody
KIAA0105 Antibody
MGC3925 Antibody
Mum2 Antibody
OTTHUMP00000017522 Antibody
OTTHUMP00000017523 Antibody
PNAS 132 Antibody
PNAS-132 Antibody
PNAS132 Antibody
Pre mRNA splicing regulator WTAP Antibody
Pre-mRNA-splicing regulator WTAP Antibody
Putative pre mRNA splicing regulator female lethal 2D homolog Antibody
Putative pre mRNA splicing regulator female lethal(2D) Antibody
Putative pre-mRNA splicing regulator female lethal(2D) homolog Antibody
putative pre-mRNA splicing regulator female-lethal(2D) Antibody
Wilms tumor 1 associated protein Antibody
Wilms tumor 1 associating protein Antibody
Wilms tumor 1-associating protein Antibody
Wilms' tumor 1 associating protein Antibody
Wilms' tumour 1-associating protein Antibody
WT1 associated protein Antibody
WT1-associated protein Antibody
WT1-associating protein Antibody
WTAP Antibody
Information:
Target information shown above is from the UniProt Consortium.
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