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Anti-WRN Antibody

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产品名称: Anti-WRN Antibody
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简单介绍

Anti-WRN Antibody


Anti-WRN Antibody  的详细介绍
Name: Anti-WRN Antibody
See all WRN primary antibodies
Description: Rabbit polyclonal antibody to WRN.
Applications: WB
Dilutions: WB: 1:200 - 1:1000.
Reactivity: Human
Immunogen: Recombinant protein of human WRN.
Protein Length: 1432
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating s for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Involvement in Disease: Werner syndrome: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction.

Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Sequence Similarities: Belongs to the helicase family. RecQ subfamily.
Post-Translational Modification: Phosphorylated by PRKDC.
Cellular Location: Nucleus > Nucleolus. Nucleus. Nucleus > Nucleoplasm.

Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.
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