产品资料

Anti-WNT5A Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-WNT5A Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-WNT5A Antibody


Anti-WNT5A Antibody  的详细介绍
Name: Anti-WNT5A Antibody
See all WNT5A primary antibodies
Description: Rabbit polyclonal antibody to WNT5A
Specificity: The antibody detects endogenous levels of total WNT5A protein.
Applications: IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide of human WNT5A
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification
Concentration: 0.6mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Tissue Specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Involvement in Disease: Robinow syndrome, autosomal dominant 1: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
Sequence Similarities: Belongs to the Wnt family.
Post-Translational Modification: Glycosylation is necessary for secretion but not for activity.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 7474?Human
  • Entrez Gene: 22418?Mouse
  • Entrez Gene: 64566?Rat
  • Omim: 164975?Human
  • SwissProt: P41221?Human
  • SwissProt: P22725?Mouse
  • SwissProt: Q9QXQ7?Rat
  • Unigene: 643085?Human
  • Unigene: 287544?Mouse
  • Unigene: 48749?Rat
    		•
    Synonyms:
  • hWNT 5A Antibody
  • hWNT5A Antibody
  • Protein Wnt 5a Antibody
  • Protein Wnt-5a Antibody
  • Protein Wnt5a Antibody
  • Wingless type MMTV integration site family member 5A Antibody
  • Wnt 5a Antibody
  • WNT 5A protein Antibody
  • WNT 5A protein precursor Antibody
  • Wnt5a Antibody
  • WNT5A protein precursor Antibody
  • WNT5A_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号