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Anti-Wnt5a Antibody

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产品名称: Anti-Wnt5a Antibody
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Anti-Wnt5a Antibody


Anti-Wnt5a Antibody  的详细介绍
Name: Anti-Wnt5a Antibody
See all Wnt5a primary antibodies
Description: Rabbit polyclonal antibody to Wnt5a
Specificity: Wnt5a pAb detects endogenous levels of Wnt5a protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Wnt5a.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 41 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Tissue Specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Involvement in Disease: Robinow syndrome, autosomal dominant 1: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
Sequence Similarities: Belongs to the Wnt family.
Post-Translational Modification: Glycosylation is necessary for secretion but not for activity.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 7474?Human
  • Entrez Gene: 22418?Mouse
  • Entrez Gene: 64566?Rat
  • Omim: 164975?Human
  • SwissProt: P41221?Human
  • SwissProt: P22725?Mouse
  • SwissProt: Q9QXQ7?Rat
  • Unigene: 643085?Human
  • Unigene: 287544?Mouse
  • Unigene: 48749?Rat
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    Synonyms:
  • hWNT 5A Antibody
  • hWNT5A Antibody
  • Protein Wnt 5a Antibody
  • Protein Wnt-5a Antibody
  • Protein Wnt5a Antibody
  • Wingless type MMTV integration site family member 5A Antibody
  • Wnt 5a Antibody
  • WNT 5A protein Antibody
  • WNT 5A protein precursor Antibody
  • Wnt5a Antibody
  • WNT5A protein precursor Antibody
  • WNT5A_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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