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Anti-Wnt3a Antibody

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产品名称: Anti-Wnt3a Antibody
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简单介绍

Anti-Wnt3a Antibody


Anti-Wnt3a Antibody  的详细介绍
Name: Anti-Wnt3a Antibody
See all Wnt3a primary antibodies
Description: Rabbit polyclonal antibody to Wnt3a
Specificity: WNT3A pAb detects endogenous levels of WNT3A protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human Wnt3a.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: 39,68 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Tissue Specificity: Moderately expressed in placenta and at low levels in ***** lung, spleen, and prostate.
Sequence Similarities: Belongs to the Wnt family.
Post-Translational Modification: Palmitoleylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleylated WNT3A from WLS in secretory vesicles (PubMed:20826466, PubMed:21244856, PubMed:24292069). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway, possibly by promoting disulfide bond formation and oligomerization (PubMed:25731175).
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 89780?Human
  • Entrez Gene: 22416?Mouse
  • Omim: 606359?Human
  • SwissProt: P56704?Human
  • SwissProt: P27467?Mouse
  • Unigene: 336930?Human
  • Unigene: 1367?Mouse
    		•
    Synonyms:
  • Protein Wnt 3a Precursor Antibody
  • Protein Wnt-3a Antibody
  • Wingless type MMTV integration site family member 3A Antibody
  • Wnt 3a Antibody
  • Wnt3a Antibody
  • WNT3A protein Antibody
  • WNT3A_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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