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Anti-WNT10B Antibody

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产品名称: Anti-WNT10B Antibody
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Anti-WNT10B Antibody


Anti-WNT10B Antibody  的详细介绍
Name: Anti-WNT10B Antibody
See all WNT10B primary antibodies
Description: Rabbit polyclonal antibody to WNT10B
Specificity: The antibody detects endogenous levels of total WNT10B protein.
Applications: WB
Reactivity: Human
Immunogen: Synthetic peptide of human WNT10B
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 3.15mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20˚C
Function: Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.
Tissue Specificity: Detected in most ***** tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.
Involvement in Disease: Split-hand/foot malformation 6: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.

Tooth agenesis, selective, 8: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant.
Sequence Similarities: Belongs to the Wnt family.
Post-Translational Modification: Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 7480 Human
  • Omim: 601906 Human
  • SwissProt: O00744 Human
  • Unigene: 91985 Human
    		•
    Synonyms:
  • Protein Wnt-10b Antibody
  • Protein Wnt-12 Antibody
  • SHFM6 Antibody
  • wingless type MMTV integration site family, member 10B Antibody
  • WN10B_HUMAN Antibody
  • WNT 10B protein Antibody
  • WNT 12 Antibody
  • Wnt10b Antibody
  • wnt12 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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