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Anti-WNT10A Antibody

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产品名称: Anti-WNT10A Antibody
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Anti-WNT10A Antibody


Anti-WNT10A Antibody  的详细介绍
Name: Anti-WNT10A Antibody
See all WNT10A primary antibodies
Description: Rabbit polyclonal antibody to WNT10A
Applications: WB
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 47 and 241 of human WNT10A
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
Involvement in Disease: Odonto-onycho-dermal dysplasia: A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.

Schopf-Schulz-Passarge syndrome: A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in *****hood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.

Tooth agenesis, selective, 4: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped.
Sequence Similarities: Belongs to the Wnt family.
Post-Translational Modification: Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Cellular Location: Secreted > Extracellular space > Extracellular matrix.
Database Links:
  • Entrez Gene: 80326 Human
  • Omim: 606268 Human
  • SwissProt: Q9GZT5 Human
  • Unigene: 121540 Human
    		•
    Synonyms:
  • FLJ14301 Antibody
  • OODD Antibody
  • Protein Wnt-10a Antibody
  • SSPS Antibody
  • STHAG4 Antibody
  • Wingless type MMTV integration site family member 10A Antibody
  • WN10A_HUMAN Antibody
  • Wnt10a Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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