产品资料

Anti-WNK1 (Phospho-Thr60) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-WNK1 (Phospho-Thr60) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-WNK1 (Phospho-Thr60) Antibody


Anti-WNK1 (Phospho-Thr60) Antibody  的详细介绍
Name: Anti-WNK1 (Phospho-Thr60) Antibody
See all WNK1 primary antibodies
Description: Rabbit polyclonal antibody to WNK1 (Phospho-Thr60)
Specificity: Phospho-WNK1 (T60) Polyclonal Antibody detects endogenous levels of WNK1 protein only when phosphorylated at T60.
Applications: WB, IHC, ELISA
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human WNK1 around the phosphorylation site of T60.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Tissue Specificity: Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron.
Involvement in Disease: Pseudohypoaldosteronism 2C: An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis in some cases, and correction of physiologic abnormalities by thiazide diuretics.

Neuropathy, hereditary sensory and autonomic, 2A: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Post-Translational Modification: O-glycosylated.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 65125?Human
  • Entrez Gene: 232341?Mouse
  • Entrez Gene: 116477?Rat
  • Omim: 605232?Human
  • SwissProt: Q9H4A3?Human
  • SwissProt: P83741?Mouse
  • SwissProt: Q9JIH7?Rat
  • Unigene: 744906?Human
  • Unigene: 333349?Mouse
  • Unigene: 27409?Rat
    		•
    Synonyms:
  • Erythrocyte 65 kDa protein Antibody
  • HSAN2 Antibody
  • HSN2 Antibody
  • hWNK1 Antibody
  • KDP Antibody
  • KIAA0344 Antibody
  • Kinase deficient protein Antibody
  • MGC163339 Antibody
  • MGC163341 Antibody
  • p65 Antibody
  • PPP1R167 Antibody
  • PRKWNK1 Antibody
  • Prostate derived sterile 20 like kinase Antibody
  • Protein kinase lysine deficient 1 Antibody
  • Protein kinase lysine-deficient 1 Antibody
  • Protein kinase with no lysine 1 Antibody
  • Protein phosphatase 1, regulatory subunit 167 Antibody
  • PSK Antibody
  • Serine/threonine protein kinase WNK1 Antibody
  • Serine/threonine protein kinase WNK1 1 Antibody
  • Serine/threonine protein kinase WNK1 2 Antibody
  • Serine/threonine-protein kinase WNK1 Antibody
  • With no K Antibody
  • WNK lysine deficient protein kinase 1 Antibody
  • WNK lysine deficient protein kinase 1 isoform Antibody
  • WNK1 Antibody
  • WNK1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号